Table 2. Genotype frequencies of BCL2 among case and control subjects and their associations with risk of lung cancer.
| Genotypes | Cases, n (%) | Controls, n (%) | OR(95% CI)* | P * |
| BCL2_rs2279115 | ||||
| −938C/A | ||||
| CC | 378(37.2) | 393(38.6) | Reference | – |
| CA | 483(47.5) | 479(47.1) | 1.02(0.83–1.25) | 0.862 |
| AA | 156(15.3) | 145(14.3) | 1.11(0.84–1.47) | 0.474 |
| BCL2_rs1801018 | ||||
| +21A>G | ||||
| AA | 855(84.1) | 846(83.2) | Reference | – |
| AG | 152(14.9) | 159(15.6) | 0.92(0.71–1.19) | 0.513 |
| GG | 10(1.0) | 12(1.2) | 0.95(0.39–2.33) | 0.916 |
| AG+GG | 162(15.9) | 171(16.8) | 0.92(0.72–1.18) | 0.513 |
| BCL2_rs1564483 | ||||
| c*1204G>A | ||||
| GG | 433(42.6) | 368(36.2) | Reference | |
| GA | 461(45.3) | 506(49.8) | 0.78(0.64–0.95) | 0.016 |
| AA | 123(12.1) | 143(14.1) | 0.73(0.54–0.98) | 0.038 |
| GA+AA | 584(57.4) | 649(63.8) | 0.76(0.63–0.93) | 0.007 |
| P trend * | 0.010 | |||
| BCL2_Haplotypes† | ||||
| C-A-G | 817(40.2) | 763(37.5) | Reference | – |
| C-A-A | 422(20.7) | 501(24.6) | 0.81(0.67–0.98) | 0.028 |
| A-A-G | 406(20.0) | 378(18.6) | 1.02(0.83–1.25) | 0.847 |
| A-A-A | 217(10.7) | 210(10.3) | 0.98(0.76–1.27) | 0.879 |
Note: Associations were determined for haplotypes >5% frequency.
*
Data were calculated by unconditional logistic regression models, adjusted for age, smoking status, pack-year smoked, and family history of cancer.
†
Polymorphic bases were in the order of rs2279115 C>A, rs1801018 A>G, rs1564483 G>A from 5′ to 3′. Frequencies of haplotypes were determined using THESIAS v3.1 software.