Table 3. Stratification analysis for associations between BCL2 rs1564483 (c*1204G>A) genotypes and risk of lung cancer.
Variables | GG | GA | AA | GA+AA | P trend | P interaction | |||
OR | OR(95%CI) | P | OR(95%CI) | P | OR(95%CI) | P | |||
Age | 0.008 | ||||||||
≤60 | 1.00 | 0.91(0.68–1.21) | 0.519 | 0.77(0.50–1.17) | 0.214 | 0.88(0.67–1.15) | 0.343 | 0.220 | |
>60 | 1.00 | 0.66(0.49–0.88) | 0.005 | 0.71(0.46–1.09) | 0.116 | 0.67(0.51–0.88) | 0.004 | 0.017 | |
Smoking status | 0.659 | ||||||||
Never-smokers | 1.00 | 0.72(0.48–1.10) | 0.126 | 0.75(0.40–1.41) | 0.375 | 0.73(0.49–1.08) | 0.117 | 0.188 | |
Smokers | 1.00 | 0.83(0.67–1.04) | 0.109 | 0.75(0.54–1.03) | 0.076 | 0.81(0.66–1.00) | 0.049 | 0.043 | |
Pack-years smoked | 0.913 | ||||||||
≤26 | 1.00 | 0.79(0.54–1.15) | 0.223 | 0.90(0.53–1.53) | 0.704 | 0.82(0.57–1.16) | 0.263 | 0.452 | |
>26 | 1.00 | 0.81(0.61–1.08) | 0.152 | 0.67(0.44–1.02) | 0.062 | 0.78(0.59–1.02) | 0.073 | 0.044 | |
Family history of cancer | 0.124 | ||||||||
No | 1.00 | 0.74(0.60–0.92) | 0.006 | 0.71(0.52–0.97) | 0.030 | 0.73(0.60–0.90) | 0.003 | 0.005 | |
Yes | 1.00 | 1.34(0.62–2.90) | 0.453 | 0.96(0.29–3.27) | 0.959 | 1.26(0.61–2.61) | 0.534 | 0.743 |
Note: ORs and P values were obtained from logistic regression models with adjustment for age, smoking status, pack-year smoked, and family history of cancer.