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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: J Thromb Haemost. 2013 Aug;11(8):1556–1564. doi: 10.1111/jth.12306

Figure 2. TALENs-mediated VKOR knockout in HEK293 cells.

Figure 2

(A) Functional screening of VKOR knockout HEK293 cells. The black and gray bars represent the concentrations of carboxylated FIXgla-PC in the cell culture medium when cells were fed with KO and vitamin K, respectively. Non-transfected cells produce similar levels of carboxylated FIXgla-PC when cultured with either vitamin K or KO [13]. (B) TALENs-mediated gene editing of VKOR locus in HEK293 cells. The wild-type VKOR target sequence is shown on the top. The ATG start codon is underlined. Deletions are indicated by dashes.