Panel A: Schematic representation of the experimental procedure. Saliva collection was performed at basal level (before pump placement), 1 week after the fist dose of RT, and 2, 3, 4, 6 and 8 weeks post-RT. Panel B: Whole saliva measurement at different time points by treatment group normalized to the body weight and basal saliva level. Note that the curves diverge around week 2 after RT and the difference was statistitcally significant (* p < 0.05). Panel C: Mean body weight at different time points by treatment group. No significant difference was observed.