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TRPV1−/− mice are protected from severe EAE. (A) Daily clinical scores of B6, TRPV1+/− and TRPV1−/− mice following immunization with MOG35–55 peptide and pertussis toxin (n = 20 per group, ***p < 0.0001). (B) Survival curve following induction of EAE with pertussis toxin (n = 20 per group, *p < 0.05). (C) Proportion of mice with severe EAE (n = 20 per group, ***p < 0.0001).
