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. 2013 May 10;19(1):149–159. doi: 10.2119/molmed.2012.00329

Figure 6.

Figure 6

TRPV1 increases the permeability of the BBB and BSCB. (A–B) Quantification of Evans Blue in regions of the brain (A, n = 5 per group, *p < 0.05, ***p < 0.001) and the spinal cord (B, n = 5 per group, *p < 0.05, ***p < 0.001) of B6 and TRPV1−/− mice at indicated time points after induction of EAE, or after injection with MOG35–55 or pertussis toxin alone. (C) Representative images of brain and spinal cord tissue dissected from B6 and TRPV1−/− mice 11 d after immunization following Evans Blue injection. (D) Representative images of B6 and TRPV1−/− whole spinal cord (upper) and sectioned spinal cord (lower) following injection of infrared-labeled IgG 11 d after immunization. (E) Representative images of B6 and TRPV1−/− whole brain (upper left: coronal and lower left: transverse) and sectioned brain (upper, middle, and lower right) following injection of infrared-labeled IgG 11 d after immunization. (F) Average intensity readings in the lumbar and thoracic regions of the spine following MRI of B6 and TRPV1−/− mice 11 d after immunization.