De novo induction of Ucn1 in exocrine acinar cells. Pancreatic sections were stained with anti-Ucn1 antibody and visualized under a confocal microscope. Representative sections are shown from saline-treated WT (A, D, G), caerulein-treated (+ Cae) WT (B, E, H), and caerulein-treated Crhr2−/− (C, F, I) pancreatic sections (60×; inset magnification: 173×) from male and female mice (n = 6/group).