Fig. 5.

Superimposed averaged mean currents (pA/pF) generated by 25 s voltage ramps from −100 to +50 mV in 9 keratinocytes exposed sequentially to Krebs’ solution (control, black), 10 μM retigabine (amber) and 10 μM XE991 (violet). 100 µM LaCl₂ was subsequently added to 7 of the same 9 cells (brown). Currents were leak-subtracted by subtracting extrapolated linear currents from −100 to −60 mV. Inset means ± SEMs of current amplitudes at +50 mV. C control, R retigabine, X XE991. Means ± SEMs (pA/pF) were: control, 1.06 ± 0.23 (n = 9); retigabine, 1.35 ± 0.33 (n = 9); XE991, 0.94 ± 0.33 (n = 9); La³⁺, 0.40 ± 0.26 (n = 7). For the bracketed columns, P values (two-tailed t test) were: * <0.05; ** <0.03