Fig. 6. Transgenic overexpression of amphiregulin in mouse skin promotes lymphangiogenesis.
Keratin14-amphiregulin (K14-AR) transgenic mice and age-matched wildtype mice were studied at 7 days of age. Paraffin-embedded sections of ear and tail skin were stained for LYVE-1 (red). The lymphatic vessel area (a), size (b), and density (c) were assessed by computer-assisted morphometric image analysis. Representative microscopic images are shown. Lymphatic vessels are highlighted by arrowheads (d, e, f, g). Data are expressed as absolute values per animal. Bars represent mean values.