. Author manuscript; available in PMC: 2014 Nov 1.

Published in final edited form as: Biomech Model Mechanobiol. 2013 Feb 3;12(6):1115–1125. doi: 10.1007/s10237-012-0467-7

Table 3.

Morphological (outer diameter – OD, wall thickness – WT) and biological (collagen content – OHP and cross-linking – PYD, percentage of type I and III collagen) parameters measured for large PAs.

Genotype		OD at 40 mmHg (μm)	WT at 40 mmHg (μm)	OD at 5 mmHg (μm)	OHP (μg/vessel)	PYD (nmol/vessel)	Type III collagen (%)	Type I collagen (%)
Col1a1^+/+	Normoxia	1189±46	30±3	633±17	0.9±0.1	0.17±0.02	30±3	70±3
	Hypoxia	970±46 ^*	47±4 ^*	583±19	1.7±0.1 ^*	0.28±0.03 ^*	24±3	76±3
	Hypoxia+BAPN	971±57 ^*	33±3 ^†	553±20 ^*	1.4±0.1 ^*	0.20±0.01 ^†	28±8	72±8
Col1a1^R/R	Normoxia	1139±24	30±4	582±15	1.2±0.1	0.17±0.03	20±2	80±2
	Hypoxia	992±34 ^*	45±3 ^*	557±12	1.8±0.1	0.25±0.03	44±4 ^*	56±4 ^*
	Hypoxia+BAPN	1070±35	38±3	573±17	2.6±0.2 ^*^†	0.22±0.02	35±5 ^*	65±5 ^*

Means±SE are shown.

P<0.05,

vs. normoxia,

^†

vs. hypoxia.

N = 5–8 per group.