Table 6.
Clinicopathologic correlations based on the timing of the onset of RBD relative to the onset of other neurologic features among subjects with PSG-confirmed or probable RBD who underwent autopsy.
| Onset of RBD relative to onset of other featuresa | Synucleinopathy pathology |
|---|---|
| RBD preceded other features | 83/87 = 95% |
| RBD preceded other features by ≥5 y | 51/53 = 96% |
| RBD preceded other features by ≥10 y | 29/30 = 97% |
| RBD preceded other features by ≥15 y | 16/17 = 94% |
| RBD preceded other features by ≥20 y | 10/10 = 100% |
| RBD occurred concurrently with other features | 26/27 = 96% |
| RBD evolved after other features | 51/57 = 89% |
a
Other features refers to cognitive impairment, parkinsonism and/or autonomic dysfunction.