Table 1. Survey of distal and non-canonical NR binding rates in genome-wide studies.
Studies are organized by NR (1st column) and cell type (2nd column). The species of the cell type is noted in parentheses (h = human, m = mouse). The published percentage of NR binding sites within ~10kb of the TSS is shown in the 3rd column (the exact distance threshold is shown in parentheses). The published percentage of NR sites containing a canonical motif is shown in the 4th column (in some studies, only the percentage of less stringent half-site motifs are reported, designated by “1/2”). Unreported values are indicated by “-”.
| NR | Cell Type | % Promoter | % Canonical Motif |
|---|---|---|---|
| ERα4 | MCF-7 (h) | - | 49% |
| ERα14 | MCF-7 (h) | 4% (1kb) | 15% |
| ERα16 | MCF-7 (h) | 7% (5kb) | 68% |
| ERα15 | MCF-7 (h) | 5% (5kb) | 71% |
| ERα23 | MDA-MB-231 (h) | 10% (1kb) | 47% |
| AR44 | LNCaP (h) | - | 10% |
| GR57 | 3T3-L1 (m) | - | 77% |
| GR17 | 3134 (m) | 7% (2.5kb) | 50% |
| GR48 | A549 (h) | 12% (10kb) | 62% |
| GR39 | Macrophages (m) | 6% | 60% |
| VDR58 | Lymphoblastoid (h) | <25% (5kb) | 67% |
| VDR59 | THP-1 (h) | 15-20% (10kb) | 32% |
| VDR20 | LS180 (h) | 2% (1kb) | 54% |
| PPARγ19 | 3T3-L1 (m) | 10% (5kb) | 44% |
| PPARγ18 | 3T3-L1 (m) | 13% (10kb) | 75% |
| PPARγ60 | Macrophage (m) | - | 70-77% |
| LXR:RXR24 | Liver (m) | 11% (5kb) | - |
| LXR61 | Macrophages (m) | 15% (500bp) | 6.3% |
| FXR62 | Liver (m) | 15% (10kb) | - |
| FXR62 | Intestine (m) | 17% (10kb) | - |
| Rev-erbα35,63 | Liver (m) | 21% (10kb) | 65% (1/2) |
| ERRα64 | Heart (m) | - | 69% (1/2) |
| ERRα65 | MCF-7, SKBr3 (h) | - | ~75% |
| ERRγ64 | Heart (m) | - | 74% (1/2) |
| RARα/γ66 | MEF (m) | - | 50% |
| RARα/γ66 | ESC (m) | - | 41% |
| RAR67 | Motor Neurons (m) | - | ~50% |
| RARα/γ26 | MCF-7 (h) | <35% (10kb) | - |
| RARα25 | MCF-7 (h) | 5% | - |
| HNF4α68 | Liver (h) | <25% (3kb) | 85% |
| HNF4α68 | Liver (m) | <25% (3kb) | 96% |