Table 3.
Tail immersion method: effects of methanolic extract of Nyctanthes arbor-tristis stem barks and morphine on pain induced tail immersion method.
| Group | Dose (mg/kg) | Reaction time in (sec) | ||||
|---|---|---|---|---|---|---|
| 0 min | 15 min | 30 min | 60 min | 90 min | ||
| Control | — | 3.02 ± 0.12 | 2.98 ± 0.17 | 2.85 ± 0.10 | 3.08 ± 0.14 | 3.06 ± 0.11 |
| Standard | 5 (i.p) | 3.06 ± 0.14 a* | 5.23 ± 0.04 a@ | 7.58 ± 0.12 a@ | 9.72 ± 0.12 a@ | 9.15 ± 0.13 a@ |
| MENA250 | 250 (p.o) | 3.04 ± 0.05 a*b* | 3.74 ± 0.13 a@b@ | 4.26 ± 0.11 a@b@ | 5.34 ± 0.18 a@b@ | 5.67 ± 0.20 a@b@ |
| MENA500 | 500 (p.o) | 2.98 ± 0.21 a*b*cns | 3.89 ± 0.05 a@b@c* | 5.44 ± 0.10 a@b@c@ | 6.71 ± 0.15 a@b@c@ | 7.52 ± 0.16 a@b@c@ |
Data are expressed as Mean ± SEM, n = 6 animals in each group. One-way ANOVA was carried out using Turkey's multiple comparison tests. Comparisons were made between:
a: Control versus Standard, MENA250, and MENA500.
b: Standard versus MENA250 and MENA500.
c: MENA250 versus MENA500.
Symbols represent statistical significance: *P < 0.05, # P < 0.01, @ P < 0.001, ns: nonsignificant.