Table 5.
Rate of edema formation.
| Group | Dose (mg/kg) | Increase in edema (%) | |||||
|---|---|---|---|---|---|---|---|
| 0 hr | 1 hr | 2 hr | 3 hr | 4 hr | 5 hr | ||
| Control | — | — | 36.25 ± 0.11 | 77.32 ± 0.14 | 96.43 ± 0.43 | 103.14 ± 0.13 | 100.41 ± 0.23 |
| Standard | 100 (p.o) | — | 18.34 ± 0.34 a# | 31.12 ± 0.16 a# | 37.14 ± 0.41 a# | 27.34 ± 0.45 a# | 19.32 ± 0.34 a# |
| MENA250 | 250 (p.o) | — | 25.12 ± 0.16 a#b@ | 51.26 ± 0.13 a#b@ | 62.32 ± 0.32 a#b@ | 56.57 ± 0.22 a#b@ | 48.43 ± 0.21 a#b@ |
| MENA500 | 500 (p.o) | — | 27.45 ± 0.17 a#b@c@ | 47.32 ± 0.14 a#b@c@ | 55.31 ± 0.43 a#b@c@ | 45.42 ± 0.20 a#b@c@ | 34.21 ± 0.24 a#b@c@ |
Data are expressed as Mean ± SEM, n = 6 animals in each group. One-way ANOVA was carried out using Turkey's multiple comparison tests. Comparisons were made between:
a: Control versus Standard, MENA250, and MENA500.
b: Standard versus MENA250 and MENA500.
c: MENA250 versus MENA500.
Symbols represent statistical significance: *P < 0.05, # P < 0.01, @ P < 0.001, ns: nonsignificant.