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(a) Illustration of intracellular delivery of plasmid DNA to the nucleus of a cancer cell using ROS-cleavable poly(amino thioketal) (PATK). After the DNA/PATK polyplexes have been internalized by the cancer cell and escaped from the endosome, ROS-triggered degradation of the PATK facilitates the intracellular release of DNA from the particle, leading to enhanced gene transfection. (b) Synthetic scheme of ROS-responsive PATK.
