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Luteolin dose-dependently relaxes phenylephrine (PE)-constricted rat aortic rings. After depolarized with KCL and washed with KH buffer, the rings were precontracted by 1 μmol/L PE for 15 min. Cumulatively increasing doses of luteolin were added to the bath containing the rings, and tension after each addition of luteolin was recorded for 15 min. Data are expressed as mean ± SE from three separate experiments. * P<0.05 vs. vehicle-treated control.
