Figure 5.
Combination gemcitabine (Gem) and SGT-53 significantly decreased murine metastatic pancreatic cancer tumor burden and enhanced tumor apoptosis, Treatment groups were evaluated at day 19 after intrasplenic Panc02 cell injection, (a) Human p53 protein expression was observed only in the SGT-53-treated group by western blot, (b) Significant differences in liver weight were demonstrated in the combination group associated with (c) enhanced apoptosis based on the terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay. *P < 0.05; **P < 0.001.