Table 2.
Presents the bone quality measures using micro computed tomography assessed at 5 and 8 wk
|
5 wk |
8 wk |
|||
| NOD (n = 4) | NOD.scid (n = 4) | NOD (n = 6) | NOD.scid (n = 4) | |
| Body weight | 14.9 ± 0.2 | 19.2 ± 0.41 | 19.2 ± 0.5 | 19.9 ± 0.6 |
| BMC | 0.19 ± 0.01 | 0.30 ± 0.011 | 0.30 ± 0.02 | 0.30 ± 0.01 |
| BMD | 0.030 ± 0.001 | 0.040 ± 0 .002 | 0.040 ± 0.001 | 0.040 ± 0.001 |
| Tibia strength | 4.5 ± 0.2 | 10.0 ± 0.8 | 8.4 ± 0.7 | 8.2 ± 0.8 |
| Trabecular bone properties | ||||
| TV | 1.4 ± 0.2 | 1.6 ± 0.1 | 1.50 ± 0.06 | 1.40 ± 0.04 |
| BV | 0.08 ± 0.02 | 0.14 ± 0.01 | 0.11 ± 0.02 | 0.16 ± 0.05 |
| BV/TV | 0.05 ± 0.021 | 0.09 ± 0.00 | 0.07 ± 0.01 | 0.11 ± 0.041 |
| Tb. Tk | 0.05 ± 0.01 | 0.05 ± 0.00 | 0.05 ± 0.00 | 0.05 ± 0.01 |
| Tb. N | 2.0 ± 0.31 | 2.8 ± 0.3 | 2.40 ± 0.09 | 2.90 ± 0.58 |
| Tb. TMV | 63.8 ± 4.9 | 108.9 ± 7.41 | 104.3 ± 8.9 | 137.0 ± 14.6 |
| Tb. TMD | 872.7 ± 42.5 | 930.5 ± 17.6 | 891.8 ± 21.3 | 948.8 ± 65.2 |
| Cortical bone properties | ||||
| TV | 0.18 ± 0.021 | 0.23 ± 0.02 | 0.20 ± 0.02 | 0.20 ± 0.02 |
| BV | 0.10 ± 0.02 | 0.14 ± 0.02 | 0.12 ± 0.00 | 0.11 ± 0.01 |
| BV/TV | 0.60 ± 0.03 | 0.60 ± 0.01 | 0.63 ± 0.011 | 0.58 ± 0.01 |
| Ct. TMV | 743.5 ± 56.9 | 787.4 ± 21.5 | 831.0 ± 13.2 | 753.0 ± 16.21 |
| Ct. TMD | 1262.9 ± 18.9 | 1324.1 ± 20.8 | 1304.3 ± 11.0 | 1258.6 ± 13.4 |
1
Indicates significant difference between groups P < 0.05. BMC: Bone mineral content; BMD: Bone mineral density; BV: Bone volume; TV: Total volume (bone plus marrow); BV/TV: Bone volume fraction; Tb. Tk: Trabecular thickness; Tb. N: Trabecular number; Tb. TMV: Trabecular material volume; Tb. TMD: Trabecular material density; Ct. TMV: Total cortical material volume; Ct. TMD: Total cortical material density; NOD: Non-obese diabetic; NOD.scid: Syngenic non-diabetic.