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. 2013 Jun 21;169(6):1290–1304. doi: 10.1111/bph.12210

Figure 1.

Figure 1

KCNQ channel inhibitors enhance spontaneous contractile activity of bladder strips. (A) An example of the effect of XE991 (10 μM) on myogenic spontaneous activity in a detrusor strip. (B) Linopirdine (Lino; 50 μM) also augmented the amplitude of spontaneous contractions. (C) Example of the increase in contraction amplitude by chromanol 293B (Chr; 30 μM). (D) Summary bar chart of the effect of KCNQ inhibitors on contractility measured as area under curve (AUC) and expressed relative to control (100%). (E) Summary bar chart of the effect of KCNQ inhibitors on frequency. (F) Summary of the effect of KCNQ inhibitors on contraction amplitude. All experiments were carried out in the presence of tetrodotoxin (1 μM). *P < 0.05, significantly different from control.