Table 3.

Impact of FoxOs in the regulation of mTORC1 activity

nFoxO1↑	GHR↓, hepatic IGF-1↓, Akt↓	mTORC1↓
nFoxO1↑	IGFBP-1↑, free IGF-1↓, Akt↓	mTORC1↓
nFoxO1↑, nFoxO3↑, nFoxO4↑	Sestrin3↑, AMPK↑, TSC2↑	mTORC1↓
nFoxO1↑	AR↓, mTORC2↓, Akt↓ AR↓, LAT↓, Regulator↓	mTORC1↓
nFoxO1↑	4E-BP-1↑	mTORC1↓
nFoxO1↑	Rictor↑, mTORC2 assembly↑	mTORC1↓
nFoxO1↑	Trb3↑, Akt↓	mTORC1↓
nFoxO3↑	Bnip3↑, Rheb↓	mTORC1↓
nFoxO3↑	FoxO1↑ TSC1↑	mTORC1↓
cFoxO1↑	TSC1/TSC2↓, Rheb↑	mTORC1↑

nFoxO, nuclear FoxO; cFoxO, cytoplasmic FoxO; LAT, L-type amino acid transporter.