TABLE 1.
Baseline Demographics (No Significant Difference Between Groups Excepting Calprotectin, P = 0.048)
| Once Daily (n = 103) | Three Times Daily (n = 110) | All Patients | ||
|---|---|---|---|---|
| Agea | 49.5 (15.0) | 50.0 (14.9) | 50.4 (14.9) | |
| Genderb | Male | 51.5 (53) | 50.0 (55) | 50.7 (108) |
| Maximum documented extent of UCb | Extensive | 30.1 (31) | 30.8 (33) | 30.0 (64) |
| Left-sided or sigmoid | 61.2 (63) | 50.5 (54) | 54.9 (117) | |
| Proctitis | 8.7 (9) | 18.7 (20) | 13.6 (29) | |
| Smoking statusb | Nonsmoker | 46.6 (48) | 46.4 (51) | 46.5 (99) |
| Current smoker | 6.8 (7) | 14.5 (16) | 10.8 (23) | |
| Exsmoker | 46.6 (48) | 39.1 (43) | 42.7 (91) | |
| Employment statusb | In full-time employment | 51.5 (53) | 49.1 (54) | 50.2 (107) |
| Not in full-time employment | 48.5 (50) | 50.9 (56) | 49.8 (106) | |
| Disease duration (years)c | 3.0 (1.0, 10.0) | 5.0 (2.0, 13.0) | 4.0 (1.5, 12.5) | |
| Number of relapses in past two yearsc | 1.0 (1.0, 2.0) | 1.0 (1.0, 2.0) | 1.0 (1.0, 2.0) | |
| Duration of remission (months)c | 6.0 (3.0, 11.5) | 6.0 (3.0, 13.0) | 6.0 (3.0, 12.0) | |
| Calprotectin result (mg/kg stool)c | 62.1 (20.3, 120.4) | 89.0 (32.0, 180.6) | 78.0 (23.3, 159.4) | |
| Baseline sigmoidoscopic scoreb | Normal (0) | 76.7 (79) | 65.5 (72) | 70.9 (151) |
| Not normal (1) | 23.3 (24) | 34.5 (38) | 29.1 (62) | |
| Baseline 5-aminosalicylic acid medicationb | Asacol | 75.7 (78) | 73.6 (81) | 74.6 (159) |
| Pentasa | 13.6 (14) | 11.8 (13) | 12.7 (27) | |
| Balsalazide | 5.8 (6) | 8.2 (9) | 7.0 (15) | |
| Other | 4.8 (5) | 6.3 (7) | 5.6 (12) | |
| Baseline 5-aminosalicylic acid dose frequency | Once | 7.9 (8) | 7.3 (8) | 7.5 (16) |
| Twice | 47.5 (48) | 52.3 (57) | 49.3 (105) | |
| Three times | 43.6 (44) | 40.4 (44) | 41.3 (88) | |
| Four times | 1.0 (1) | 0 (0) | 0.5 (1) | |
| Azathioprine or 6-mercaptopurine useb | 10.7 (11) | 12.7 (14) | 11.7 (25) |
a
Mean (standard deviation).
b
Percentage (number of patients).
c
Median (interquartile range).