Figure 4.

Lipid-Protein Interactions Are Short Lived

(A) Distribution of fractional protein contact times for individual DMPC lipids during 1μs CG-MD simulation of the 2B6O Aqp0 structure. A residue that interacts with a lipid throughout the simulation has a value of one.

(B) Phosphate particle positions, shown for every frame within the bilayer plane, for a lipid that had the most protein contacts over the course of the simulation, indicated by the arrow in (A). The backbone trace of the central Aqp0 tetramer is shown in gray.