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. Author manuscript; available in PMC: 2013 Aug 19.
Published in final edited form as: Physiol Rev. 2012 Jul;92(3):1479–1514. doi: 10.1152/physrev.00022.2011

FIGURE 1.

FIGURE 1

Structure of yeast Sir2 in complex with an acetyl-ribosyl-ADP intermediate. Yeast Sir2 is depicted in the cartoon representation with the zinc binding site highlighted in cyan, the helical module highlighted in magenta, and the Rossmann foldlike NAD+ binding site highlighted in orange. The acetyl-ADP intermediate is depicted as a stick representation with carbon atoms in gray, oxygen atoms in red, nitrogen atoms in blue, sulfur atoms in yellow, and phosphate atoms in orange. The structure was assembled from Protein Data Bank code 2HJH (Protein Data Bank: Hall BE, Buchberger JR, Gerber SA, Ambrosio ALB, Gygi SP, Filman D, Moazed D, Ellenberger T.).