Table 3.
Comparison of P-values for each variable, obtained from the applied regression methods on CAC in AGES-Reykjavik 2002-2006 (n = 5,213). Models fitted for each variable separately by sex, adjusting for age and excluding people with history of coronary events
Males |
Females |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Modelled as: | ZINB- logistic part |
ZINB- count part |
Linear regression ln(CAC+1) |
Linear regression Box-Coxc |
Quantile regression |
ZINB- logistic part |
ZINB- count part |
Linear regression ln(CAC+1) |
Linear regression Box-Coxc |
Quantile regression |
|
Physical and physiological | |||||||||||
BMI | Continuous | * | *** | *** | *** | *** | |||||
Systolic blood pressure (10 mmHg) | Continuous | * | ** | ** | *** | *** | *** | ||||
Pulse pressure (10 mmHg) | Continuous | * | *** | ** | *** | *** | *** | ||||
Total serum cholesterol (mmol/L) | Continuous | * | ** | ||||||||
HDL cholesterol (mmol/L) | Continuous | ** | *** | *** | *** | *** | |||||
Triglycerides (mmol/L) | Continuous | ** | ** | *** | *** | *** | |||||
C-reactive protein (mg/L) | Continuous | * | ** | ** | ** | *** | *** | *** | |||
Diabetes mellitus, type II (No is reference) | Categorical | ** a | * a | ** a | ** a | *** a | |||||
Newly diagnosed | * | ||||||||||
Previously known diabetes | ** | * | ** | * | ** | ** | *** | ||||
Smoking Never (reference) | Categorical | ** a | *** a | *** a | *** a | *** a | *** a | *** a | *** a | ||
Former | ** | * | *** | *** | *** | ** | *** | *** | *** | ||
Current | ** | ** | *** | *** | *** | *** | *** | ||||
Cardiovascular profile | |||||||||||
Family history of myocardial infarction | Categorical | ** | ** | *** | *** | *** | *** | *** | *** | *** | |
Chest pain from heart disease | Categorical | * | ** | ** | |||||||
Mini stroke or TIA | Categorical | * | * | * | |||||||
Carotid intima thickness (mm) | Continuous | *** | *** | *** | *** | *** | *** | *** | *** | *** | |
Plaque, moderate or more in carotid artery | Categorical | *** | *** | *** | *** | *** | *** | *** | *** | *** | *** |
Medications | |||||||||||
Analgesics | Categorical | * | ** | *** | *** | *** | * | *** | *** | *** | *** |
Anticoagulants | Categorical | *** | *** | *** | *** | * | ** | *** | *** | *** | |
Aspirin | Categorical | *** | *** | *** | *** | * | ** | *** | *** | *** | |
Statins | Categorical | *** | *** | *** | *** | *** | ** | *** | *** | *** | |
Medication for hypertension | Categorical | ** | *** | *** | *** | *** | ** | *** | *** | *** | *** |
| |||||||||||
Total number of associations b | 7 | 12 (13) | 12 | 13 | 13 | 16 | 15 (17) | 18 | 17 | 18 |
P-value <0.05
P-value <0.01
P-value <0.001
Abbreviations: BMI, Body mass index; CAC, Coronary artery calcium; HDL, High density lipoprotein; TIA , Transient ischemic attack; ZINB, Zero inflated negative binomial
P-value from Wald-test, Ho: all coefficients=0
Total number of associations from the ZINB-model shown in parenthesis.
Power transformation 0.20 (95% CI 0.19, 0.21)