FIG. 5.

EPC integrate into damaged vessel walls and are not merely associated perivascularly with vessels. Two-color fluorescent immunohistology of frozen sections of mouse eyes with intravitreous huEPC shows green mouse endothelial cells (arrows) in the superficial, middle, and deep vascular plexi of the neural retina of both normal control (n = 4) (panel A) and STZ-diabetic (n = 4) (panel B) mice. However, only in the diabetic mouse eye in panel B are there red huEPC (arrowheads), which align with the mouse endothelium. V = vitreous; INL = inner nuclear layer; IPL = inner plexiform layer.