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. 2013 Jul 26;24(8):766–775. doi: 10.1089/hum.2012.132

FIG. 1.

FIG. 1.

Schematic illustration of vectors and viruses used in this study, with detailed illustrations of the SCG3 promoter and ASH1 enhancer. (A) Ad5(CMV-Luc), Ad5(SCG3-Luc), and Ad5(ASH1-SCG3-Luc) are E1-deleted Ad5-based vectors with luciferase gene expression controlled by the CMV promoter, the 0.5-kb human SCG3 promoter, and the 0.5-kb human SCG3 promoter and 0.2-kb human ASH1 enhancer, respectively. Ad5(MOCK) and Ad5PTD(MOCK) are E1-deleted replication-defective control viruses. The oncolytic adenoviruses Ad5PTD(WT) and AD5PTD(ASH1-SCG3-E1A) as well as Ad5PTD(MOCK) have a Tat-PTD modification in the hexon HVR5 region. (B) An illustration of the putative SCG3 promoter and ASH1 enhancer, which are used to control Luc or E1A expression.

HHS Vulnerability Disclosure