Figure 4.

Global distribution of frequencies of HMs, four NLRP7 NSVs, and countries of origin of unrelated patients with mutations in KHDC3L and NLRP7 genes. (a) Epidemiology of HMs. Countries with low incidences are in white, countries with middle incidences (2-fold increase) are in yellow and those with high incidences (up to 10-fold) are in red. (b–e) Distribution of the minor allele frequencies of four NSVs in NLRP7 according to data from the 1000 Genomes database. Ancestral alleles are indicated by their colors. (f) Distribution of the countries of origin of patients with NLRP7 (black dots) and KHDC3L (red dots) mutations.