Table 1. Description of the seven genes and count of rare variants per gene.

	Total number of variants	Number of rare variants (MAF <1%)	Median MAF	Coding length (base pairs)	Number of individuals with different counts of rare variants
					0	1	2	3	≥4
Gene 1	49	42	2.50E−04	2002	1882	112	4	0	0
Gene 2	103	90	2.54E−04	4094	1707	223	34	4	1
Gene 3	29	27	2.52E−04	1239	1905	74	2	0	0
Gene 4	64	54	5.08E−04	1638	1719	240	9	0	0
Gene 5	68	62	2.54E−04	1963	1771	176	20	2	0
Gene 6	67	54	5.08E−04	2901	1735	223	10	0	1
Gene 7	128	105	5.01E−04	1500	1709	262	24	2	1