Illustration demonstrating binding of gold nanoparticles (G2, G40, G70 for 2, 40, 70 nm diameter) functionalized with Herceptin antibodies, which recognize receptors on the cell surface. Arrows indicate ErbB2 receptors, and the nucleus is counterstained in blue with 4,6-Diamidino-2-phenylindole, scale bar = 10 μm. From Jiang et al[94], reproduced with permission from Nature Publishing Group. AuNP: gold nanoparticles.