Table 2.
Methylation of a CTCF binding region is correlated with the T2D risk variant rs2334499
| % Methylation Mean (SE)a |
Effectb | P-valuec | |
|---|---|---|---|
| CpG-1 | 22.9 (0.9) | −5.7 | 6.5×10−7 |
| CpG-2 | 15.3 (0.7) | −3.1 | 0.00055 |
| CpG-3 | 13.3 (0.8) | −2.5 | 0.017 |
| CpG-4 | 56.7 (0.9) | −8.4 | 2.6×10−13 |
| CpG-5 | 34.9 (0.9) | −6.7 | 6.8×10−8 |
| CpG-6 | 22.2 (0.6) | −1.0 | 0.24 |
| CpG-7 | 52.9 (1.1) | −1.5 | 0.30 |
a
% Methylation at each site shown is the mean and the standard error (SE) of the C/T ratio estimated by bisulfite sequencing of 168 individuals.
b
Change in percentage methylation per allele T of rs2334499 carried.
c
Significance of the correlation between methylation and rs2334499.