Table 3.
sychiatric and Substance Abuse History Among African Americans (N=154)
| 5-HTTLPR Genotype | ||||
|---|---|---|---|---|
| L’L’ (n=38) |
L’S’ (n=87) |
S’S’ (n=28) |
p-value | |
| Lifetime Anxiety Disorder (%) | 21.4 | 20.6 | 14.3 | 0.79 |
| Lifetime Major Depression (%) | 17.9 | 19.0 | 4.8 | 0.29 |
| Baseline Depressive Symptoms | ||||
| BDI score [mean, (SD)] | 8.29 (7.1) | 7.89 (6.9) | 5.96 (4.7) | 0.33 |
| Baseline Severity of Depression (%) | 73.7 | 72.7 | 82.1 | 0.38 |
| None (BDI<=10) | 13.2 | 8.0 | 10.7 | |
| Minimal (BDI=11–14) | 0.0 | 9.1 | 7.1 | |
| Mild (BDI=15–19) | 13.2 | 10.2 | 0.0 | |
| Moderate (BDI=20–29) | 0.0 | 0.0 | 0.0 | |
| Severe (BDI>=30) | ||||
| Lifetime Alcohol Use Disorder (%) | 42.9 | 41.3 | 42.9 | 0.99 |
| Lifetime Drug Use Disorder (%) | 50.0 | 36.5 | 52.4 | 0.30 |
| Medications at Baseline (% of patients) | ||||
| Anxiolytics | 10.5 | 3.4 | 3.6 | 0.23 |
| SSRIs Antidepressants | 15.8 | 15.9 | 7.1 | 0.49 |
| Non-SSRIs Antidepressants | 10.5 | 14.8 | 0.0 | 0.094 |