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. Author manuscript; available in PMC: 2013 Aug 19.
Published in final edited form as: Leukemia. 2011 May 13;25(8):1370–1374. doi: 10.1038/leu.2011.98

Figure 3. Hypothesis of depletion of Oct-4+ epiblast-derived VSELs in adult bone marrow by chronic Ins/Igf signaling in bGH transgenic mcie.

Figure 3

Epiblast-derived VSELs are deposited in developing tissues including bone marrow as a backup population of SCs for production of tissue committed stem cells. We envision that in bone marrow VSELs are a backup population for long term repopulating hematopoietic stem cells (LT-HSCs) that give rise to hematopoietic stem/progenitor cells (HSPCs). Prolonged signaling by Insulin, Igf1, and Igf2 (e.g., due to high caloric uptake or as result of GH overexpression in bGH transgenic mice) may lead to premature depletion of these cells. A decrease in the number of VSELs in bone marrow will directly affect a pool of LT-HSC and finally over time also HSPCs.