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. Author manuscript; available in PMC: 2013 Aug 19.
Published in final edited form as: Cytokine. 2012 Apr 13;59(1):108–114. doi: 10.1016/j.cyto.2012.03.018

Figure 8. Effect of Th17 cell-derived IL-21 on B-cell Ig production.

Figure 8

Splenic B cells from wild-type (n = 3) and IL-21R−/− (n = 3 to 4) mice were co-cultured with in vitro skewed Th17 cells derived from OTII mice in the presence and absence of OVA323-339 peptides for 6 days. The levels of IgA, IgE, IgG1, IgG2b, IgG2c and IgG3 in the culture supernatants were measured by ELISA. Data show the mean ± SEM. *p<0.05, **p<0.01 vs. Medium; and †p<0.05, ††p<0.01 vs. wild-type B cells.