Table 3.
Univariate analysis of clinical and histopathologic variables
| Variable | Number of patients |
Survival rate |
P value | |
| 3-yr | 5-yr | |||
| Age (yr) | 0.222 | |||
| < 60 | 41 | 34.15% | 17.07% | |
| ≥ 60 | 37 | 24.32% | 18.92% | |
| Sex | 0.523 | |||
| Female | 46 | 28.26% | 17.39% | |
| Male | 32 | 31.25% | 18.75% | |
| Cholelithiasis | 0.374 | |||
| Present | 25 | 24.00% | 16.00% | |
| Absent | 53 | 32.08% | 18.87% | |
| Type of radical resection | 0.179 | |||
| Extended cholecystectomy | 7 | 42.86% | 42.86% | |
| Partial hepatectomy1 | 37 | 32.43% | 13.51% | |
| Partial hepatectomy and EBD resection | 23 | 30.43% | 26.09% | |
| Extended hepatectomy2 | 5 | 0.00% | 0.00% | |
| Hepatopancreaticoduodenectomy | 6 | 50.00% | 33.33% | |
| Hepatic infiltration | 0.005 | |||
| Present | 41 | 14.63% | 4.88% | |
| Absent | 37 | 51.35% | 37.84% | |
| Bile duct infiltration | 0.238 | |||
| Present | 17 | 29.41% | 23.53% | |
| Absent | 61 | 32.79% | 19.67% | |
| Venous invasion | 0.001 | |||
| Present | 10 | 0.00% | 0.00% | |
| Absent | 68 | 36.76% | 23.53% | |
| Perineural invasion | 0.539 | |||
| Present | 9 | 22.22% | 22.22% | |
| Absent | 69 | 33.33% | 20.29% | |
| Lymph node involvement | < 0.001 | |||
| Present | 37 | 16.22% | 13.51% | |
| Absent | 41 | 46.34% | 26.83% | |
| pT classification3 | 0.001 | |||
| pT0-pT2 | 20 | 60.00% | 45.00% | |
| pT3-pT4 | 58 | 22.41% | 12.07% | |
| pN classification3 | < 0.001 | |||
| pN0 | 41 | 46.34% | 26.83% | |
| pN1 | 31 | 16.13% | 12.90% | |
| pN2 | 6 | 16.67% | 16.67% | |
| pM classification3 | 0.002 | |||
| pM0 | 74 | 33.78% | 21.62% | |
| pM1 | 4 | 0.00% | 0.00% | |
| TNM staging3 | < 0.001 | |||
| 0-II | 15 | 80.00% | 60.00% | |
| III | 43 | 23.26% | 11.63% | |
| IV | 20 | 15.00% | 10.00% | |
| TLNC | 0.018 | |||
| < 4 | 26 | 15.38% | 7.69% | |
| ≥ 4 | 52 | 40.38% | 26.92% | |
| Number of positive lymph nodes | < 0.001 | |||
| 0 | 41 | 46.34% | 26.83% | |
| < 3 | 24 | 16.67% | 16.67% | |
| ≥ 3 | 13 | 15.38% | 7.69% | |
| LNR | < 0.001 | |||
| 0 | 41 | 46.34% | 26.83% | |
| < 50 | 15 | 33.33% | 33.33% | |
| ≥ 50 | 22 | 4.55% | 0.00% | |
| Histological type | 0.706 | |||
| Adenocarcinoma | 69 | 33.33% | 20.29% | |
| Others | 9 | 22.22% | 22.22% | |
| Histological grade | 0.042 | |||
| G1-G2 | 58 | 36.21% | 24.14% | |
| G3-G4 | 19 | 15.79% | 5.26% | |
1
Includes wedge resection and resection of segments IVa and V;
2
Includes extended right hepatectomy, extended left hepatectomy and central hepatectomy;
3
According to the American Joint Committee on Cancer cancer staging manual (7th edition). G1: Well differentiated; G2: Moderately differentiated; G3: Poorly differentiated; G4: Undifferentiated; EBD: Endoscopic balloon dilatation; TNM: Tumor node metastasis; TLNC: Total lymph node count; LNR: Lymph node ratio.