Table 3. Summary of studies showing freedom from biochemical relapse after high dose rate (HDR) brachytherapy combined with external beam radiotherapy (EBRT), according to risk group.

Reference	Dose schedule	No. of patients	Low risk (%)	Intermediate risk (%)	High risk (%)	End point (years)
Aström et al [34]	EBRT: 50 Gy @ 2 Gy per fraction	214	100	100	86	4
	HDR: 2×10 Gy per fraction
Flynn et al [38]	NAHT: 86%	674	97	92	72	5
	EBRT: 45 Gy @ 1.8 Gy per fraction
	HDR: 15.5–21.0 Gy in 3 or 4 fractions
Galalae et al [33]	EBRT: 45.6−50.0 Gy @ 1.8–2.0 Gy per fraction	611	96	88	69	5
	HDR: BED 79.6–123.0 Gy
Galalae et al [39]	NAHT: 0%	324	–	85	81	5
	BED: <94 Gy vs >94 Gy
Guix et al [41]	EBRT: 46–66 Gy @ 2 Gy per fraction	445	–	95	94	5
	HDR: 2×5–8 Gy
Izard et al [43]	NAHT: median 6 months	165	100	95	67	5
	EBRT: 45.0–59.4 Gy @ 1.8 Gy per fraction
	PDR BRT: 18 Gy in 3 fractions
Martinez et al [44]	NAHT: no	207	–	85	75	5
	HDR: 5.5–11.5 Gy per fraction
Phan et al [46]	NAHT: 36%	309	100	100	97	5
	EBRT: 36.0–50.4 @ 1.8–2.0 Gy per fraction
	HDR: 22–24 Gy
Yamada et al [47]	EBRT: 45.0–50.4 Gy @ 1.8 Gy per fraction	105	100	98	92	5
	HDR: 5.5–7.0 Gy in single fraction
Pellizzon et al [45]	EBRT: 45 Gy median	209	91	90	89	5
	HDR: 20 Gy median
Agoston et al [36]	EBRT: 60 Gy median	280	–	84	82	5
	HDR: 10 Gy in single fraction
Demanes et al [37]	NAHT: no	209	93	82	62	10
	EBRT: 36 Gy @ 1.8 Gy per fraction
	HDR: 22–24 Gy in 4 fractions
Ghilezan et al [40]	NAHT: 43%	1577	–	88	74	10
	EBRT: 40 Gy median
	HDR: 24 Gy median
Hasan et al [42]		886	98	92	71	10

BED, biologically equivalent dose; NAHT, neoadjuvant hormone therapy; PDR, pulse dose rate brachytherapy.