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LM11A-31 efficacy varies with FIV load. FIV titers of 104, 105 and 106 TCID50/ml produced similar decreases in MAP-2 staining intensity. Addition of 10 nM LM11A-31 resulted in a significant recovery of MAP-2 in each case but the extent of recovery decreased from 172% (n=6) to 123% (n=7) and 56% (n=10) as the amount of FIV increased. Values are normalized to controls (100%).
