Table 2.
Oral antidiabetic agents
Drug class | Brand name | Generic name | Available strengths (mg) | Mechanisms of action | |
---|---|---|---|---|---|
Sulfonylureas | Diabeta | Glyburide | 1.25, 2.5, 5 |
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Stimulate pancreatic β cells to increase first-phase insulin secretion May cause hypoglycemia |
Micronase | Glyburide | 1.25, 2.5, 5 | |||
Glynase | Glyburide (micronized) | 1.5, 3.0, 4.5, 6.0 | |||
Glucotrol | Glipizide | 5, 10 | |||
Glucotrol XL | Glipizide | 5, 10 | |||
Amaryl | Glimepiride | 1, 2, 4 | |||
Meglitinides | Prandin | Repaglinide | 0.5, 1, 2 | ||
Starlix | Nateglinide | 60, 120 | |||
Biguanides | Glucophage | Metformin | 500, 850, 1,000 |
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↓ HGO |
Glucophage XR | Metformin | 500 | |||
Thiazoledinediones | Actos | Pioglitazone | 15, 30, 45 |
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Decrease insulin resistance |
Avandia | Rosiglitazone | 2, 4, 8 | |||
α-Glucosidase inhibitors | Precose | Acarbose | 25, 50, 100 |
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Delay glucose absorption |
Glyset | Miglitol | 5, 50, 100 | |||
Combinations | Glucovance | Glyburide/metformin | 1.25/250, 2.5/500, 5.0/500 |
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↓ HGO Decrease insulin resistance ↑ Insulin secretion |
Avandamet | Rosiglitazone/metformin | 1/500, 2/500, 4/500 | |||
Actos + mets | Pioglitazone/metformin | 15/500, 15/850 | |||
Prandimet | Metformin/repaglinide | 500/1, 500/2 | |||
DPP IV inhibitors | Januvia | Sitagliptin | 25, 50, 100 | ||
Janumet | Sitagliptin/metformin | 50/500, 50/1000 |
HGO, hepatic glucose output; DPP IV, dipeptidyl peptidase IV.