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. Author manuscript; available in PMC: 2013 Aug 19.
Published in final edited form as: Cancer Chemother Pharmacol. 2009 May 7;65(1):67–71. doi: 10.1007/s00280-009-1003-z

Table 4.

Change in measures of docetaxel pharmacokinetics

Variable Difference
Pre- to Post-JFK
P value
Concentration at 15 min 847 (−2,165, 3,859) 0.7
Concentration at 45 min −95 (−369, 179) 0.9
Area-under-the-curve at infinity 104 (−1,127, 1,335) 0.3
Area-under-the-curve at final
 time point
180 (−1,037, 1,397) 0.4
Clearance rate (L/h) 3.8 (−5.3, 13.0) 0.3
Volumes of distribution (Vd) by
 the steady-state method
−39 (−102, 24) 0.15

Data are given as difference between means and 95% CI