Table 5.
Stability data for the tamarixetin and kaempferide in rat plasma (n = 3)
| Compounds | Spiked concentration (µg/mL) |
Measured concentration (µg/mL) | ||||||||
| Short-time 4 hours |
12 hours | 24 hours | Long-time 1 day |
6 days | 30 days | Freeze-thaw 1 cycle |
2 cycles | 3 cycles | ||
| Tamarixetin | 800 160 16 |
791±10.3 155±5.06 14.7±0.700 |
770±14.7 151±4.37 14.4±0.787 |
742±17.3 146±5.65 14.0±0.668 |
792±17.5 154±1.15 15.1±0.634 |
781±19.6 153±3.90 15.0±1.22 |
777±18.6 151±4.35 14.7±0.534 |
796±14.8 153±4.53 14.9±0.708 |
778±16.8 149±3.65 14.6±0.845 |
758±15.6 147±6.16 14.1±0.827 |
| Kaempferide | 700 140 14 |
681±12.7 132±2.98 12.8±0.614 |
677±14.8 133±4.35 12.6±0.914 |
645±15.3 127±6.55 12.2±0.848 |
694±11.4 133±7.24 12.8±1.02 |
685±9.88 130±6.34 12.4±0.959 |
674±12.4 126±8.08 12.2±0.852 |
693±178 129±8.97 12.5±0.584 |
671±11.5 126±7.60 12.1±0.898 |
663±17.2 123±6.01 12.1±1.08 |