Table 6.
Stability data for the tamarixetin and kaempferide in rat tissues (n = 3)
| Compounds | Spiked concentration (µg/mL) |
Time piont |
Measured concentration (µg/mL) | |||||
| Heart | Liver | Spleen | Lung | Kindey | Brain | |||
| 3 cycles |
734±18.9 | 746±24.7 | 722±25.2 | 714±17.6 | 738±19.7 | 724±17.0 | ||
| 800 | 30 days |
750±18.8 | 741±21.5 | 738±24.7 | 693±20.3 | 734±19.2 | 717±26.1 | |
| 24 h | 730±24.7 | 726±21.4 | 714±31.7 | 660±42.6 | 705±27.7 | 682±18.9 | ||
| 3 cycles | 147±6.11 | 132±7.76 | 142±8.45 | 143±6.53 | 147±5.56 | 142±5.37 | ||
| Tamarixetin | 160 | 30 days |
142±7.60 | 146±5.44 | 146±7.16 | 137±5.73 | 143±6.82 | 140±6.88 |
| 24 h | 137±5.90 | 140±7.71 | 140±7.82 | 141±6.05 | 146±10.7 | 138±6.95 | ||
| 3 cycles | 14.4±0.678 | 14.0±0.616 | 14.4±0.442 | 13.9±0.671 | 14.4±0.879 | 13.9±0.901 | ||
| 16 | 30 days |
14.3±0.547 | 14.1±0.896 | 14.5±0.685 | 13.8±0.647 | 14.0±0.666 | 14.2±0.760 | |
| 24 h | 13.8±0.725 | 13.7±0.582 | 13.9±0.751 | 14.1±0.733 | 13.7±0.607 | 13.9±0.972 | ||
| 3 cycles |
650±13.2 | 638±21.6 | 627±22.9 | 624±23.4 | 639±24.1 | 625±24.6 | ||
| 700 | 30 days |
654±21.8 | 634±17.4 | 640±23.0 | 615±26.0 | 648±24.4 | 622±23.2 | |
| 24 h | 639±24.3 | 622±31.9 | 666±32.7 | 612±27.0 | 627±26.7 | 600±34.0 | ||
| 3 cycles |
126±4.75 | 125±5.10 | 129±4.61 | 124±6.26 | 125±5.03 | 125±5.82 | ||
| Kaempferide | 140 | 30 days |
125±5.42 | 127±4.75 | 128±5.94 | 123±5.36 | 124±5.96 | 123±7.08 |
| 24 h | 123±.61 | 122±8.32 | 124±7.95 | 121±7.55 | 121±6.56 | 121±6.29 | ||
| 3 cycles |
12.4±0.598 | 12.4±0.609 | 12.3±0.768 | 12.5±0.784 | 12.2±0.889 | 12.1±0.820 | ||
| 14 | 30 days |
12.5±0.715 | 12.5±0.792 | 12.3±0.736 | 12.3±0.997 | 12.3±0.776 | 12.3±0.738 | |
| 24 h | 12.1±0.822 | 12.0±0.885 | 12.2±1.02 | 12.0±0.942 | 12.2±0.836 | 12.0±0.931 | ||