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. 2013 May 15;38(10):1993–2002. doi: 10.1038/npp.2013.98

Figure 3.

Figure 3

P2 × 4R knockout (KO) mice exhibit communication deficits and altered sensory function. (a) Maternal separation-induced ultrasonic vocalizations are reduced in P2 × 4R KO mice compared with their wild-type (WT) counterparts. (b) P2 × 4R heterozygous (HZ) and KO mice exhibit significant reductions in latency to remove sticky tape compared with WT controls. (c) Acoustic startle amplitude was significantly lower in P2 × 4R KO mice compared with HZ and WT mice. P2 × 4R KO mice exhibit altered (d) % prepulse inhibition (PPI) and (e) delta PPI compared with WT and HZ mice. Data are shown as mean±SEM for 7–10 mice per genotype. ***P<0.001, **P<0.01, and *P<0.05 compared with WT mice. ##P<0.01 and #P<0.05 compared with HZ mice.