Table 4.

Fetal brain measures assessed during the second trimester in alcohol-exposed and comparison pregnancies

Parameter	Alcohol exposed (n = 66)*	Comparison (n = 64)*	P†	Smoking-adjusted P‡
Transverse cerebellar diameter (mm)	21.8 ± 0.2	22.0 ± 0.2	NS	NS
Occipitofrontal diameter (mm)	68.5 ± 0.6	68.3 ± 0.6	NS	NS
Caval–calvarial distance (mm)	25.6 ± 0.3	26.6 ± 0.4	< 0.05	< 0.05
Frontothalamic distance (mm)	40.5 ± 0.5	41.6 ± 0.5	NS	< 0.05
Outer orbital diameter (mm)	36.1 ± 0.3	35.9 ± 0.9	NS	NS
Interorbital distance (mm)	11.0 ± 0.2	11.3 ± 0.2	NS	NS
Orbital diameter (mm)	11.5 ± 0.2	11.6 ± 0.2	NS	NS

Values are mean ± SE.

^*Sample size might vary owing to missing values.

^†Adjusted for gestational age.

^‡Adjusted for gestational age and smoking (never/past/sometime during pregnancy). NS, not significant.