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Model of the mechanism by which the EGF-induced DMR signal is mediated in UPCI-37B SCCHN cells and its application for HTS of EGFR pathway inhibitors. The PI3K/Akt (solid arrow), but not Ras/Raf/MEK/ERK (dotted arrow) pathway, mediates the EGF-induced DMR signal in UPCI-37B SCCHN cells. Our established cell-based optical signature assay is a novel approach for the discovery of inhibitors targeting the EGFR signaling pathway through HTS.
