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. Author manuscript; available in PMC: 2013 Aug 19.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Dec 20;23(4):1022–1025. doi: 10.1016/j.bmcl.2012.12.022

Table 1.

In vitro activities of triclosan derivatives with a 1-substituent against cultured P. falciparum strains.

graphic file with name nihms458566u1.jpg
Compound R EC50 3D7 (μM) EC50 Dd2 (μM)
triclosan OH 2.9 3.8
1 OCH3 100 76
2 CN 20 43
3 COOH >150 >150
4 CONH2 73 60
5a NH2 52 55
6 CH2NH2 2.3 4.3
7 C(CH3)2NH2 7.2 1.8
8 NHSO2Me 38 60
9 NHSO2Ph 4.7 5.1
10 NHAc 33 48
11 NHBz 9.7 9.4
12 NHC(O)NH2 18 18
13 NHC(O)NHPh 0.73 1.2