Table 1.
Approximate numbers and percentages of donor-reactive activated CD4+ T cells secreting IFNγ in direct and indirect fashion after allogeneic skin or heart transplantation. Modified after Brennan et al. (this issue)
| Pathway | Skin allograft
|
Heart allotransplant
|
||||||
|---|---|---|---|---|---|---|---|---|
| LN day 10
|
LN day 60
|
Spleen day 7
|
Heart transplant day 60
|
|||||
| IFNγ spots | % response | IFNγspots | % response | IFNγ spots | % response | IFNγ spots | % response | |
| Direct | >3000 | 90% | 100 | 80% | 2200 | 95% | 50 000 | 67% |
| Indirect | 300 | 10% | 25 | 20% | 100 | 5% | 25 000 | 33% |