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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: J Neural Eng. 2013 Jun 7;10(4):046004. doi: 10.1088/1741-2560/10/4/046004

Figure 2. Two-compartment pharmacokinetics-binary observation model.

Figure 2

The pump infusion rate u(t) governs the flow of anesthetic into the central compartment. The kinetic rate parameters a12 and a21 govern the anesthetic flow between the central compartment and the brain compartment. The variable x1(t) is the amount of anesthetic in the central compartment and the variable x2(t) is the amount of anesthetic in the brain compartment. The rate parameter a10 governs the rate of anesthetic clearance from the central compartment. The observation nk is the binary form of the EEG at time t = kΔ. By Eqs. (3) to (5) the probability of observing nk is a function of x2(t).