Figure 6. BSP control in simulated rat experiments.

Each experiment uses 6 different burst suppression target levels for propofol (A, C) and etomidate (B, D). In the first experiment (A, B) control is achieved assuming that the observable is the brain level of the anesthetic, x₂(t). In the second experiments (C, D) control is achieved by using the estimated brain anesthetic level, x_2,k∣k, from the BSP filter in Eqs. (8) to (10). Control with the binary filter is demonstrated with 10 binary series realizations at each of the 6 levels for both anesthetics.