Table 1.

Composition and physicochemical properties of the prepared liposomes

DOX-liposomes	Molar ratio (DSPC/Chol/4Gal-DTPA-DSPE)	Particle size (nm)	PDI	Zeta potential (mV)	EE (%)
Conventional liposomes	55:45:0	159.1 ± 1.3	0.083 ± 0.060	−22.5 ± 2.3	94.6 ± 5.8
4Gal-liposomes (5%)	50:45:5	168.8 ± 2.6	0.079 ± 0.038	−28.1 ± 1.6	92.7 ± 7.2
4Gal-liposomes (10%)	50:40:10	164.4 ± 1.5	0.084 ± 0.027	−33.2 ± 3.5	90.4 ± 4.9

Note: (Mean ± SD, n = 3).

Abbreviations: Chol, cholesterol; DOX, doxorubicin; DSPC, 1,2-distearoyl-sn-glycero-3-phosphocholine; 4Gal-DTPA-DSPE, tetravalent galactosylated diethylenetriaminepentaacetic acid-distearoyl phosphatidylethanolamine; PDI, polydispersity index; EE, encapsulation efficiency.