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. Author manuscript; available in PMC: 2013 Aug 19.
Published in final edited form as: Pflugers Arch. 2008 Aug 29;457(5):1079–1091. doi: 10.1007/s00424-008-0579-1

Fig. 6.

Fig. 6

Effect of EPAC activation on jejunal fluid absorption and surface colonocyte NHE3 activity in WT mice. a Whereas 200 μM 8-pCPT-cAMP caused a significant inhibition of jejunal fluid absorption (*p<0.05), the same concentration of the structurally related selective EPAC activator 8-pCPT-2′-O-Me-cAMP had no effect (n=5). b In surface colonocytes, 100 μM 8-pCPT-2′-O-Me-cAMP had a small but significant inhibitory effect on the proton flux (*p<0.05), but full activation of adenylate cyclase by FSK caused a much more pronounced inhibition (**p<0.05; n=6)