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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Cancer Res. 2012 Oct 10;73(3):1086–1096. doi: 10.1158/0008-5472.CAN-12-2198

Table 2.

MCMC-based estimates of various tumor promotion and progression time scales. These identifiable parameters are defined as:λ = μ0 · X · μ1 ·p, gP = αPβPμ2, gM = αMβMρ, μ2eff=μ2·p. Here, we define p ≈ 1 − βM/αM (see SI for more details). Estimates represent medians and 95% credibility regions of the marginal posterior distribution for each quantity listed. All units are in years.

males λ (95% CI) × 10-4 gp (95% CI) gM (95% CI) μ2eff (95% CI) × 10-6

CRC 2.13 (2.10 - 2.15) 0.162 (0.160 - 0.164) 2.71 (2.22 - 4.15) 0.73 (0.55 - 0.86)

GaC 0.51 (0.49 - 0.53) 0.140 (0.135 - 0.145) 1.00 (0.80 - 1.30) 3.21 (2.16 - 4.65)

PaC 0.35 (0.34 - 0.36) 0.181 (0.177 - 0.186) 27.7 (7.44 - 49.1) 0.25 (0.21 - 0.32)

EAC 52.9 (34.8 - 99.3) 0.163 (0.133 - 0.190) 1.02 (0.68 - 2.19) 4.65 (1.65 - 10.8)

females λ (95% CI) × 10-4 gP (95% CI) gM (95% CI) μ2eff (95% CI) × 10-6

CRC 1.57 (1.55 - 1.59) 0.149 (0.147 - 0.151) 2.12 (1.75 - 2.75) 1.56 (1.26 - 1.87)

GaC 0.40 (0.36 - 0.44) 0.100 (0.096 - 0.105) 1.06 (0.91 - 1.25) 2.83 (2.36 - 3.39)

PaC 0.34 (0.33 - 0.35) 0.161 (0.157 - 0.165) 30.0 (9.10 - 50.0) 0.30 (0.26 - 0.36)

EAC 9.1 (2.4 - 30.9) 0.170 (0.132 - 0.218) 1.18 (0.86 - 1.71) 4.65 (fixed)